Diabetes is currently one of the most widespread diseases, and its prevalence is rapidly growing around the world. Diabetes is a common life- long condition and the number of children being diagnosed with type 1 diabetes is increasing. For many, diabetes means living with daily insulin injections and the possibility of long-term damage to their health.
Type 1 Diabetes is an autoimmune disease and results from T cell autoimmunity mediated destruction of the vast majority of insulin-producing pancreatic ß-cells. Therefore, the development of new therapies to control T cell autoimmunity and to preserve the remaining ß-cell function will be of great significance in managing patients with type 1 diabetes. Patients diagnosed with T1DM are reliant on exogenous insulin.
Adipose tissue derived mesenchymal stem cells have been shown in many studies their potential cure for T1DM, which could not only address the need for ß-cell replacement but also the regulation of the autoimmune response to cells which express insulin. Mesenchymal stem cells are able to control T cell autoimmunity.
In both forms of diabetes, unless treated, blood sugar will rise uncontrollably, and over time can lead to such complications as cardiovascular disease, liver disease, kidney disease (diabetic nephropathy), circulatory problems that may require limb amputation, vision loss and blindness (diabetic retinopathy), and nerve damage (diabetic neuropathy).
How is type 1 diabetes treated at the moment? People with type 1 diabetes must test their blood sugar levels several times a day and inject insulin when it is needed. Unfortunately it can still be hard to keep the sugar level normal, even with regular injections. Over time, high blood sugar levels can cause serious damage to the heart, eyes, blood vessels, kidneys and nerves, whilst injecting too much insulin can lead to a blood sugar level that's too low (hypoglycaemia) and this can be fatal.
It is possible to treat type 1 diabetes by transplanting islet cells or even a whole pancreas into the patient from a donor. Transplants can enable the body to regain control of blood sugar levels so that insulin injections are no longer needed. Islet transplantation is not very common because whole pancreas transplants involve major surgery and carry significant risk. Also the number of donors is heavily outweighed by the demand and transplants require the immune system to be suppressed so that the new "foreign" organ is not rejected. Immune suppressing drugs leave the recipient vulnerable to infection and often have side-effects.
How could stem cells help?
One of the biggest problems faced by islet transplantation is the lack of donors. Instead of using donor cells, own stem cells used in diabetes therapy.
Own stem cells
The research showed that stem cells present in the patient's pancreas are able to make new beta cells. Beta cell progenitors have been found in the pancreas of both rodents and humans; progenitor cells have some stem cell properties and can self-renew (copy themselves) indefinitely. The stem cells from the patient's own adipose tissue "re-educate" the immune system so that it no longer attacks the beta cells. The new beta cells are able to sense blood sugar levels and react accordingly.
Clinical trials inserting mesenchymal stem cells into type 1 diabetes patients take advantage of two assets these cells possess. Firstly, they have the regenerative potential to repair beta cells , and secondly they can modulate the immune system by inhibiting the responses that lead to the autoimmune attack on pancreatic beta cells. In the trials underway, the most common source of mesenchymal stem cells is adipose tissue. These trials not only prove the safety and efficacy of mesenchymal stem cells but also they replace the need for immunosuppressive drugs in future therapies. These approaches promote beta cell function, thereby reducing or eliminating the requirement for exogenous insulin.
CLERO STEM CELL CENTER has developed the Adult Autologous Stem Cell Therapy program to treat a variety of conditions. During stem cells treatment a patient receives 200 - 300 billion stem cells that in turn mean trillion plain cells. This quantity of the plain restored cells not only covers daily losses, but exceeds them in thousands times. Thus, the reserve of the stem cells, almost lost for the latest 15 - 20 years, is restored. Naturally, that after such active cell replenishment, any organ get rejuvenated and renewed, because the new and active cells displace the old and damaged ones.
1. free of side effects and rejection (use the patient's very own stem cells from their abdomen)
2. allow to avoid any allergic and immune reactions (own cells suit chromosomal and genetic structure)
3. does not require general anesthesia
4. no risk of contamination by transmissible diseases
5. no oncological complication as adult stem cells in the comparison with embryonic cells are rather mature
6. small quantity of the fat tissues is needed (that is why after activation process the stem cells can be at once injected to patient without necessity of growing them on substances. Embryonic stem cells are grown during several months)
7. the period of time between getting lipoaspirate and injection of the activated stem cells is only a few hours
8. adipose tissue stem cells are easily accessible and yielding up to ten times more stem cells than patient's bone marrow.
In CSCC we deliver treatment with proven results associated by the assistance of highly qualified professionals who realize the importance of personalized care, quality and confidence and that lead to top standards of treatment.
CLERO STEM CELL CENTER is an excellent center that offers patients
the most innovative therapies.
In principle in our medical centers we use the unique technology of application of autologous photo activated stem cells prior extracted from fat cells using mini liposuction.
The highest standards of treatment and investigative research are upheld at all times.
Contact us and our doctors will recommend you individual treatment program and offer the best stem cell therapy package.
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